WebMar 1, 2024 · It is composed primarily of laminin, nidogen, collagens, and proteoglycans. There are at least four different types of proteoglycan found within basement membranes. These proteoglycans are perlecan, agrin, … WebThe fourth class of GAG, hyaluronic acid (HA), is not sulfated and is synthesized by three …
Cells Free Full-Text Glycosaminoglycan Modification of Decorin ...
WebAggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. This gene is a member of the lectican (chondroitin sulfate proteoglycan) family.The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and … WebApr 8, 2024 · of HA to collagen content. To predict the impact of GAG-induced swelling on cellular force transmission, we developed a constitutive model for collagen–GAG cogels described by σ ij ¼ gðF ij,c col,c GAG,c Hþ, cþ,c Þ: [1] In this equation, σ ij and F ij denote the stress tensor and the deformation gradient of the collagen–GAG network ... unesco shs who\u0027s who
Structural basis of collagen fiber degradation by cathepsin K
WebJul 16, 2014 · The GAG chains provide aggrecan with its high anionic charge whereas aggregation endows it with a large size. Both the charge and size properties are essential for normal aggrecan function and hence articular cartilage function. ... Trippel SB: Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor ... WebMar 29, 2024 · This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. ... gag: Treatment of human stellate cells with HIV-1 MA upregulates the expression of … WebTendons are composed of collagen fibrils and proteoglycan predominantly consisting of decorin. Decorin is located on the d-band of collagen fibrils, and its glycosaminoglycan (GAG) chains have been observed between … unesco scholarship 2017