Web1 de fev. de 2010 · HIF-1 target genes involved in glucose and energy metabolism. HIF-1 activates the transcription of SLC2A1 and SLC2A3, which encode the glucose transporters GLUT1 and GLUT3, respectively, as well as HK1 and HK2, which encode hexokinase, the first enzyme of the Embden–Meyerhoff (glycolytic) pathway [9]. WebHIF-1 is a heterodimeric transcription factor complex, composed of two subunits: an O 2-responsive HIF-1α subunit, and a constitutively expressed HIF-1β subunit. The intact HIF-1 complex binds to hypoxia response elements (HREs) in the promoters of genes that govern diverse processes, such metabolism, proliferation, apoptosis, and angiogenesis.
HIF-1 α pathway: role, regulation and intervention for cancer …
WebNational Center for Biotechnology Information Web14 de abr. de 2024 · PKM and LDHA can affect the production and metabolism of pyruvate and lactic acid, thus affecting the citric acid cycle and leading to changes in the concentration of reactive oxygen species, thus activating the HIF-1 signaling pathway . In addition, the SNO modification of GLUD1 was detected in this study, GLUD1 ... sharp el 738 price
Hif-1α Knockdown Reduces Glycolytic Metabolism …
Web3 de jan. de 2014 · HIF-1 regulates glucose, lipid, and glutamine metabolic flux in cancer cells HIF-1 expression, via multiple target genes, enhances glycolytic metabolism, by which glucose is metabolized to lactate rather than converted to acetyl-CoA to enter TCA cycle for OXPHOS in mitochondria.As a result, cancer cells are protected against excessive ROS … Web1 de nov. de 2024 · Thus, HIF-1 can control BAT activity through both direct and indirect mechanisms. In addition, the induction of HIF activity in neuronal cells (neuron-specific … Web26 de nov. de 2009 · HIF-1 and metabolism. (A) Regulation of HIF-1α protein synthesis and stability and HIF-1-dependent metabolic reprogramming.The rate of translation of HIF-1α mRNA into protein in cancer cells is dependent upon the activity of the mammalian target of rapamycin (mTOR), which is determined by the activity of upstream tumor suppressor … sharp el 531 xtb wh