Irf8 genecards
WebNov 15, 2008 · IRF8 is known to bind to any of 4 distinct target sequences in genes subject to transcriptional activation or repression by IRF8. 29 Studies of the regulatory sequences of Sfpi1, which encodes PU.1, identified 2 possible IRF8 target sites. WebMar 10, 2011 · IRF8 is an essential transcriptional regulator of IFN-β expression in monocytes We hypothesized that IRF8, a transcription factor found only in lymphoid and myeloid cells such as macrophages, 24, 32 might be involved.
Irf8 genecards
Did you know?
WebIFN regulatory factor (IRF) 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation. Whether IRF8 plays a role in the development and function of microglia, the tissue-resident myeloid cells of … WebGeneCards Team; Log In / Sign Up; My Genes; Showing 25 of 1,697 results for acap1 Search Time: 0 ms in NEW (Click on the icon in the table below to see search hit context) Showing of 1,697 Results for acap1 Search Time: 0 ms. Export Show: Symbol Description Category UniProt ID GIFtS GC id Score ...
WebFeb 15, 2008 · IRF8 binds to certain DNA motifs such as ISRE and Ets/IRF composite elements by interacting with partner proteins that include IRF members and Ets family proteins. 12, 15 Although IRF8 can regulate gene expression through other mechanisms, the interaction with partners is thought to be a critical requirement for macrophage … WebProtein Interferon regulatory factor 8 Gene Irf8 Status UniProtKB reviewed (Swiss-Prot) Organism Mus musculus (Mouse) Amino acids 424 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function
WebJan 14, 2024 · MalaCards Gene Search: IRF8 Diseases sorted by gene-association score: immunodeficiency 32a, mycobacteriosis, autosomal dominant* (1650), immunodeficiency … WebInterferon regulatory factor 8 (Irf8), also known as interferon consensus sequence-binding protein, is a component of the Irf transcription factor family. Irf8 is differentially expressed …
WebAug 8, 2024 · IRF8 is a key regulator of innate immunity receptor signaling and plays diverse functions in the development of hematopoietic cells. The effects of IRF8 on hematopoietic stem cells (HSCs) are still unknown. Here, it is demonstrated that IRF8 deficiency results in a decreased number of long-term HSCs (LT-HSCs) in mice.
WebMar 25, 2024 · IRF8 has also been found to be expressed and functional in non-hematopoietic cells such as epithelial cells [ 7, 8 ]. Studies of IRF8 mRNA levels in normal human colon and colorectal carcinoma (CRC) revealed that IRF8 is downregulated in tumor tissues as compared to non-malignant counterpart tissues. inception shot drinkIn myeloid cells, IRF8 regulates the expression of Bax and Fas to regulate apoptosis. In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediate CML apoptosis. IRF8 is highly expressed in myeloid cells and was originally identified in as a critical lineage-specific transcription factor for myeloid cell differentiation, recent studies, however, have shown that IRF8 is also constitutively expressed in non-hematopoietic cancer cells, albeit at a lower leve… inception short summaryWebNov 17, 2024 · IRF8 R294C mice were crossed with C57BL/6 wild-type female for at least three generations to eliminate the vertical transmission of Murine Leukemia Virus (MuLV). Progenies were crossed to generate the mice carrying homozygous alleles for the mutation, and all the mice were used at the age of 8–12 weeks. inception shot recipeWebMar 29, 2024 · Detroit, city, seat of Wayne county, southeastern Michigan, U.S. It is located on the Detroit River (connecting Lakes Erie and St. Clair) opposite Windsor, Ontario, … inability to tolerate heatWebIRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias. PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human … inability to think logicallyWebThe strengths of this test include: CAP accredited laboratory; CLIA-certified personnel performing clinical testing in a CLIA-certified laboratory inception similar moviesWebOct 4, 2024 · IRF8, or ICSBP, is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. The family also includes IRF1 ( 147575 ), IRF2 ( 147576 ), and ISGF3 (see … inception sinopse