Webavapritinib Anti-neoplastic Agents itraconazole 7.90 (PBPK) CYP3A avoid strong CYP3A inhibitors relugolix Anti-neoplastic Agents erythromycin 6.25 P-gpa avoid oral P-gp inhibitors;if unavoidable, separate dose of at least 6 h lonafarnib Other ketoconazole 5.07 CYP3Ab contraindicated with strong or moderate CYP3A inhibitors; avoid weak WebPBPK models have been used by drug developers to predict and evaluate the effect of various intrinsic and extrinsic patient factors, alone or in combination, on the exposure of investigational ...
Paclitaxel - Pfizer
WebApr 2, 2024 · To Assess the Bioavailability and Safety of Paclitaxel Injection Concentrate for Suspension in Subjects With Locally Recurrent or Metastatic Breast Cancer The safety … WebPBPK modeling-based optimization of site-specific chemo-photodynamic therapy with far-red light-activatable paclitaxel prodrug Author links open overlay panel Mengjie Li a , Luong Nguyen a , Bharathiraja Subramaniyan a , Moses Bio a , Cody J. Peer b , Jessica Kindrick b , William D. Figg b , Sukyung Woo a , Youngjae You a how to turn off ignore time limit
A Physiologically Based Pharmacokinetic Model to Predict …
WebJun 26, 2024 · Paclitaxel-Model Whole-body PBPK model of paclitaxel Repository files Within this repository, we distribute a whole-body PBPK model of Paclitaxel, that has … WebFeb 28, 2024 · BCS class IV drugs (e.g., amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel) exhibit many characteristics that are problematic for effective oral and per oral delivery. Some of the problems associated include low aqueous solubility, poor permeability, erratic and poor absorption, inte … Webpaclitaxel [pak″lĭ-tak´sel] an antineoplastic agent that acts by promoting and stabilizing the polymerization of microtubules, isolated from the Pacific yew tree (Taxus brevifolia); used … ordinary serum for oily skin