WebSep 1, 2024 · This GPL thioester reductase domain has received considerable structural and mechanistic characterization as summarized in Section 2.2 and maintains an overall homology of 45–50% with reductase domains that reduce the thioester to an aldehyde or an alcohol or catalyze a Dieckmann cyclization . 22, 23. Go to: 4. ... WebThioester-containing proteins (TEP) are large secreted proteins playing central roles in the innate immune response [ 1, 2 ]. TEP are characterized by the presence of a unique intrachain β-cysteinyl-γ-glutamyl thioester bond (CGEQ) originally discovered in the human protease inhibitor, α-2-macroglobulin (A2M), and complement C3 and C4 [ 3 ].
Revision in the first steps of the biosynthesis of the red antibiotic ...
WebAug 17, 2024 · The hydrolyzed thioester domain of C3 undergoes structural change exposing the binding site for Factor B. Mg 2+ is the only ion required for functional activation of the alternative pathway that stabilizes the interaction between C3b and factor B. Webcl26778: TED Superfamily. Thioester domain. This domain is found near the N-terminus of a variety of bacterial surface proteins and pili. This domain contains an unusual covalent ester bond between a conserved cysteine and glutamine residue. Links. clicks marketing definition
Complement Receptor 3 Forms a Compact High-Affinity …
WebMar 16, 2024 · The N-terminal region of the adhesin contains a class II type thioester domain (TED) that is essential for efficient conjugation, particularly in liquid medium. We … WebHECT domain. In molecular biology, the HECT domain is a protein domain found in ubiquitin-protein ligases. The name HECT comes from ' H omologous to the E 6-AP C arboxyl T erminus'. [1] Proteins containing this domain at the C terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. WebJun 8, 2008 · Like C3 and TEP, C5 contains eight MG domains (MG1–MG8), a CUB domain, the C5d domain (structurally homologous to the thioester-containing TE domain in C3 and TEP), the C5a domain (also... clicks marketing